If you take a proton pump inhibitor (PPI) such as esomeprazole, pantoprazole, omeprazole or rabeprazole for reflux, you may wonder whether it has any effect on your CPAP therapy.
The reassuring answer is that PPIs don't directly interfere with how your CPAP machine works, and CPAP doesn't directly stop a PPI from working.
However, reflux, sleep apnoea and CPAP can interact in interesting ways.
PPIs reduce the amount of acid produced by the stomach. If night-time reflux is causing coughing, throat irritation, discomfort or repeated waking, controlling those symptoms may make sleep — and potentially CPAP use — more comfortable. Research has investigated whether treating reflux with PPIs also improves obstructive sleep apnoea itself, but the evidence isn't strong enough to conclude that PPIs significantly improve the number of apnoeas or hypopnoeas. (PubMed Central (PMC))
CPAP may actually improve night-time reflux in some people. Studies have found that people who use their CPAP consistently can experience improvements in nocturnal reflux symptoms. (PubMed)
There is one complication to watch for: aerophagia, or swallowing air during CPAP therapy. This can cause belching, bloating and abdominal discomfort, and research has found an association between CPAP-related aerophagia and reflux. Higher CPAP pressures and existing GORD may increase the likelihood of aerophagia. (PubMed)
Could successful CPAP mean I no longer need my PPI?
Possibly your reflux symptoms could improve — but don't stop your PPI on that basis without having it reviewed.
If you've been using CPAP consistently and notice that your night-time reflux has substantially improved, it's worth discussing your PPI with your pharmacist or doctor. They can determine whether you still need the same medicine and dose.
Likewise, if you've started CPAP and developed new bloating, excessive belching or worsening reflux, have your CPAP therapy reviewed rather than simply increasing your reflux medication. Sometimes the issue may be related to aerophagia and your CPAP setup or pressure. (PubMed)
The takeaway: PPIs and CPAP don't directly interfere with each other. But because reflux, OSA and CPAP therapy are interconnected, improvement or deterioration in one area can be a good reason to review the other.
Book an appointment to discuss any medication related issues.